Contribution of mass spectrometry for the detection of xenobiotics implicated in cases of drug-facilitated crimes and the quantitation of urinary metabolites of polycyclic aromatic hydrocarbons

University of Health and Law. I am grateful to my supervisor Prof. Dr. Michel Lhermitte for his advice, encouragement and support as well as his patience during the past few years. I wish to thank members of the " Forensic Toxicology Unit " , CHRU de Lille, namely L. Humbert, J-F Wiart and C.Richeval, for creating favourable working conditions, placing their excellent analytical facilities and skilful analytical assistance at my disposal during the work, as well as their warm friendship during the past few years. My warmest thanks and gratitude go to Dr. assistance and patience during the practical work as well as his advice, constructive criticism and expert comments on the manuscript and warm friendship during the past few years. Also, I would like to thank the technical assistants and secretarial offices at CHRU de Lille, as well as the Université de Lille 2, for their assistance.